(D)-PPA 1

Research use only, not for human use.

PD-1/PD-L1 interaction inhibitor. Binds to PD-L1 (Kd = 0.51 μM). Inhibits interaction at 1 mg/mL in flow cytometry. Inhibits tumor growth and prolongs survival time of mice in vivo.

PD-1/PD-L1 interaction inhibitor. Binds to PD-L1 (Kd = 0.51 μM). Inhibits interaction at 1 mg/mL in flow cytometry. Inhibits tumor growth and prolongs survival time of mice in vivo.

Cell Viability Assay Cell Line:CT26 cells Concentration:3.125, 6.25, 12.5, 25, 50, and 100 μM Incubation Time:24 hours, 48 hours Result:Left tumor cells growing normally.

Animal Model:CT26-tumor-bearing Balb/c miceDosage:2 mg/kg Administration:1) Subcutaneous injection, for around the tumor once every day for 7 days.2) Intraperitoneal injection, once every day for 7 days.3) Intraperitoneal injection, once every day for 12 days; recorded the survival on day 13 Result:Inhibited tumor growth, and prolonged the survival in mice.

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Immunology/Inflammation

PD-1/PD-L1

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1620813-53-7

1555.67

C70H98N20O21

>98% (HPLC)

water:2 mg/mL

[H]N[C@H](CC(N)=O)C(=O)N[C@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](CO)C(=O)N[C@H](CCCCN)C(=O)N1CCC[C@@H]1C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](CC1=CNC=N1)C(=O)N[C@H](CC1=CC=CC=C1)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years